ABSTRACT
Recurrent aphthous stomatitis [RAS] is one of the most common and the most pathologic status of oral soft mucosa. Frequencies of RAS is between%10 and%20 in population. Numerous agents have been evaluated in the treatment of RAS with mixed results. These agents include antihistamines, anesthetics, vitamins, Levamisole, antibiotics and corticosteroids. The aim of this study was to compare the efficacy of Irsha and Persica mouthrinses on RAS. Thirty - nine patients with recurrent aphthous stomatitis were selected for this double blind clinical trial trial [21 females and 18 males]. Twenty patients were assigned to use Irsha [group A] and nineteen to use Persica [group B] mouth rinse, twice a day for 30 seconds. This base population was identified by clinical examination of aphthous ulceration and based on specific criteria for clinical diagnosis, including appearance, location, size and number of lesions. The results were analyzed by Wilcoxon and Mann - whitney U tests. In three months treatment, the mean value was respectively 18.5 for Irsha and 21.25 for Persica. There was no significant difference between them. Both Irsha and Persica significantly reduced the duration and severity of RAS as compared with baseline in a protocol that included clinical diagnosis, individual patient baseline evaluation and pervision of each patient during the study. According to this study Persica and Irsha mouth rinses have similar effects on RAS. Both of them reduce pain, sore and duration of healing and can be used for treatment of RAS